Trazodone hydrochloride
Base Information
- Chemical Name:Trazodone hydrochloride
- CAS No.:25332-39-2
Manufacturers supply cost-effective and customizable Trazodone hydrochloride 25332-39-2
- Molecular Formula:C19H23Cl2N5O
- Molecular Weight:408.331
- Vapor Pressure:2.94E-11mmHg at 25°C
- Melting Point:223oC
- Boiling Point:528.5 °C at 760 mmHg
- Flash Point:273.4 °C
- PSA：45.78000
- LogP:3.16660
Trazodone hydrochloride(Cas 25332-39-2) Usage
|
Therapeutic Function |
Tranquilizer |
|
Biochem/physiol Actions |
Antidepressant that potentiates the activity of serotonin uptake blockers and has full 5-HT2C serotonin receptor agonist activity. It is metabolized to the 5-HT1 serotonin receptor agonist 1-(3-Chlorophenyl)piperazine. |
|
Drug interactions |
Potentially hazardous interactions with other drugs Alcohol: increased sedative effects. Antidepressants: avoid concomitant use with MAOIs and moclobemide. Antiepileptics: antagonism of anticonvulsant effect; concentration reduced by carbamazepine. Antimalarials: manufacturer advises avoid concomitant use with artemether and lumefantrine and piperaquine with artenimol. Antivirals: concentration increased by ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid; concentration possibly increased by telaprevir. |
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Metabolism |
Trazodone is hepatically metabolised via the cytochrome P450 isoenzyme CYP3A4 by n-oxidation and hydroxylation. The metabolite m-chlorophenylpiperazine is active. Trazodone is excreted in the urine almost entirely in the form of its metabolites. |
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Definition |
ChEBI: A hydrochloride salt prepared from equimolar amounts of trazodone and hydrogen chloride. |
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General Description |
Trazodone is a antidepressant drug sold under trade names such as Desyrel? and Oleptro? for treatment of anxiety disorder, depression, and insomnia. Trazadone, a serotonin antagonist and reuptake inhibitor (SARI), also has anti-anxiety and hypnotic effects. This certified Snap-N-Spike? solution is suitable for use in clinical toxicology, forensic analysis, or urine drug testing methods by LC-MS/MS or GC/MS. |
InChI:InChI=1/C19H22ClN5O.ClH/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25;/h1-3,5-7,9,15H,4,8,10-14H2;1H
25332-39-2 Relevant articles
Microwave-assisted synthesis of trazodone and its derivatives as new 5-HT1A ligands: Binding and docking studies
Jaskowska, Jolanta,Zar eba, Przemys?aw,Sliwa, Pawe?,Pindelska, Edyta,Sata?a, Grzegorz,Majka, Zbigniew
, (2019/05/01)
Trazodone, a well-known antidepressant d...
CONTINUOUS PROCESS FOR THE PREPARATION OF TRAZODONE
-
, (2019/08/29)
The present invention relates to an impr...
Preparation method of trazodone hydrochloride
-
Paragraph 0046; 0047, (2016/12/01)
The invention is applicable to the field...
AN IMPROVED PROCESS FOR THE PREPARATION OF TRAZODONE AND HYDROCHLORIDE SALT THEREOF
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Page/Page column 19; 20, (2015/08/06)
The present invention provides an improv...
25332-39-2 Process route
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52605-52-4
1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride
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-
1,2,4-triazolo<4,3-a>pyridin-3(2H)-one sodium salt
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25332-39-2,19666-36-5
trazodone hydrochloride
| Conditions | Yield |
|---|---|
|
With
tetrabutylammomium bromide; sodium carbonate;
In
isopropyl alcohol;
at 80 - 85 ℃;
for 12h;
Reagent/catalyst;
|
83% |
-
![2-(3-bromopropyl)[1,2,4]triazolo[4,3-a]pyridine-3(2H)-one](/upload/2026/11/05d7a5beb3dd46fe8773e002c8fa8a4f_a4a7f2de-25ee-40d3-a9ba-0c37cad0009c.png)
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1094305-62-0
2-(3-bromopropyl)[1,2,4]triazolo[4,3-a]pyridine-3(2H)-one
-
-
13078-15-4,51639-49-7,65369-76-8
1-(3-chlorophenyl)piperazine hydrochloride
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-
25332-39-2,19666-36-5
trazodone hydrochloride
| Conditions | Yield |
|---|---|
|
2-(3-bromopropyl)[1,2,4]triazolo[4,3-a]pyridine-3(2H)-one; 1-(3-chlorophenyl)piperazine hydrochloride;
With
tetrabutylammomium bromide; potassium carbonate;
In
N,N-dimethyl-formamide;
for 0.0166667h;
Microwave irradiation;
With
hydrogenchloride;
In
1,4-dioxane; acetone;
Solvent;
Reagent/catalyst;
|
98% |
25332-39-2 Upstream products
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19794-93-5
trazodone
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52605-52-4
1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride
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109-09-1
2-chloropyridine
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6969-71-7
[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
25332-39-2 Downstream products
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55290-68-1
4‐(3‐chlorophenyl)‐1‐(3‐(3‐oxo‐[1,2,4]triazolo[4,3‐a]pyridin‐2(3H)‐yl)propyl)piperazine 1‐oxide
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220910-12-3
2-(3-((2-((3-chlorophenyl)amino)ethyl)amino)propyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one