Benidipine
Base Information
- Chemical Name: Benidipine
- CAS No.: 105979-17-7
China cas 105979-17-7 factory wholesale Benidipine at affordable price
- Molecular Formula: C28H31N3O6
- Molecular Weight: 505.571
- Vapor Pressure: 1.5E-15mmHg at 25°C
- Refractive Index: 1.621
- Boiling Point: 625.2 °C at 760 mmHg
- PKA: pKa 7.34(H2O(long extrapolation) ) (Uncertain)
- Flash Point: 331.9 °C
- PSA： 113.69000
- Density: 1.29 g/cm3
- LogP: 5.00030
Benidipine(Cas 105979-17-7) Usage
|
Enzyme inhibitor |
This oral, once-daily antihypertensive agent (FW = 505.57 g/mol; CAS 105979-17-7), also known by its code name KW-3049, trade name Coniel?, and systematic name O -methyl,O -[(3R)-1-(phenylmethyl)piperidin-3-yl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, is a dihydropyridine-class calcium ion blocker that is effective against L-, N-, and T-channels, with potent and selective inhibitory action on cardiac slow calcium channels. Benidipine bound stereospecifically to nitrendipine binding sites of rat myocardium with high affinity (Ki = 0.13 nM) and to the rat brain a1-adrenergic receptor (Ki = 1.2 μM). KW-3049 exhibited no remarkable binding affinity to a2 adrenergic, b-adrenergic, D2 dopamine, H1 histamine, S2 serotonin, A1 adenosine, A2 adenosine and muscarinic cholinergic receptors at 100 μM. |
InChI:InChI=1/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1
105979-17-7 Relevant articles
THERAPY FOR COMPLICATIONS OF DIABETES
-
, (2009/07/02)
A method for enhancing glycemic control ...
ANTIHYPERTENSIVE THERAPY
-
, (2009/09/08)
A new use of darusentan is provided in p...
Synthesis and pharmacological activity of stereoisomers of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 1-(phenylmethyl)-3-piperidinyl ester
Muto,Kuroda,Kawato,Karasawa,Kubo,Nakamizo
, p. 1662 - 1665 (2007/10/02)
1,4-Dihydro-2,6-dimethyl-4-(3-nitropheny...
105979-17-7 Process route
-
-
6859-99-0
3-hydroxypiperazine
-
-
105979-17-7,119065-61-1,119065-60-0,91599-75-6
benidipine
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
3
steps
2: triethylamine / toluene / 5 h / Heating
3: dimethylformamide; CH2
Cl2
/ 2 h
With
triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
|
-
-
62414-68-0
(3R)-piperidin-3-ol
-
-
105979-17-7,119065-61-1,119065-60-0,91599-75-6
benidipine
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1: triethylamine / toluene / 5 h / Heating
2: dimethylformamide; CH2
Cl2
/ 2 h
With
triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
|
105979-17-7 Upstream products
-
88712-56-5
methyl (R)-5-chlorocarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
-
91599-81-4
(R)-N-benzyl-3-hydroxypiperidine
-
6859-99-0
3-hydroxypiperazine
-
62414-68-0
(3R)-piperidin-3-ol