Sulindac

Sulindac Good Supplier In Bulk Supply High Purity 38194-50-2 We provide high quality Sulindac (CAS 38194-50-2), at a very affordable prices to our customers.

1.What is the Sulindac ?

Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans. Sulindac is one of the older NSAIDs, an isostere of indomethacin developed before the inducible form of COX-2 was discovered. Although a number of NSAIDs have been found to protect against digestive tract cancers, sulindac has an extensive epidemiology documenting reduced human colorectal cancer. In murine models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels.

Sulindac (Clinoril) is chemically related to indomethacin and is generally used for the same indications. It is a prodrug that is metabolized to an active sulfide metabolite and an inactive metabolite. The most frequently reported side effects are GI pain, nausea, diarrhea, and constipation. The incidence of these effects is lower than for indomethacin, presumably because sulindac is a prodrug and thus the active metabolite is not highly concentrated at the gastric mucosa. As with indomethacin, a rather high incidence of CNS side effects (dizziness, headache) also occurs.

Sulindac is a non-steroidal anti-inflammatory drug.

2.What is the CAS number for Sulindac ?

The CAS number of Sulindac is 38194-50-2.

More information of Sulindac 38194-50-2 are:

3.What is the molecular formula of Sulindac ?

The chemical formula of?Sulindac is C20H17FO3S which containing 20 Carbon atoms,17 Hydrogen atoms,1 Fluorine atoms,3 Oxygen atoms and 1 Sulfur atoms,and the molecular weight, and the molecular weight of Sulindac is 356.418

4.What is Sulindac(38194-50-2)used for?

Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans. Sulindac is one of the older NSAIDs, an isostere of indomethacin developed before the inducible form of COX-2 was discovered. Although a number of NSAIDs have been found to protect against digestive tract cancers, sulindac has an extensive epidemiology documenting reduced human colorectal cancer. In murine models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels.

InChI:InChI=1/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+

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5.Sulindac Good Supplier In Bulk Supply High Purity 38194-50-2

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