5-Chlorovaleryl chloride
Base Information
- Chemical Name: 5-Chlorovaleryl chloride
- CAS No.: 1575-61-7
Good factory exports good 5-Chlorovaleryl chloride 1575-61-7
- Molecular Formula: C5H8Cl2O
- Molecular Weight: 155.024
- Appearance/Colour: clear colourless to slightly yellow liquid
- Vapor Pressure: 0.586mmHg at 25°C
- Refractive Index: n20/D 1.464(lit.)
- Boiling Point: 188.9 °C at 760 mmHg
- Flash Point: 76.3 °C
- PSA： 17.07000
- Density: 1.183 g/cm3
- LogP: 2.16090
5-Chlorovaleryl chloride(Cas 1575-61-7) Usage
|
Flammability and Explosibility |
Notclassified |
|
General Description |
5-Chlorovaleroyl chloride is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals. |
InChI:InChI=1/C5H8Cl2O/c6-4-2-1-3-5(7)8/h1-4H2
1575-61-7 Relevant articles
Synthesis and characterization of a Gd(III) based contrast agent responsive to thiol containing compounds
Carrera, Carla,Digilio, Giuseppe,Baroni, Simona,Burgio, Daniela,Consol, Simona,Fedeli, Franco,Longo, Dario,Mortillaro, Armando,Aime, Silvio
, p. 4980 - 4987 (2007)
A novel Gd(iii) complex with a modified ...
Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival
Podunavac, Ma?a,Mailyan, Artur K.,Jackson, Jeffrey J.,Lovy, Alenka,Farias, Paula,Huerta, Hernan,Molgó, Jordi,Cardenas, Cesar,Zakarian, Armen
supporting information, p. 11278 - 11282 (2021/04/19)
The scalable synthesis of the oxaquinoli...
Synthesis of N-trifluoromethyl amides from carboxylic acids
Flavell, Robert R.,Liu, Jianbo,Parker, Matthew F. L.,Toste, F. Dean,Wang, Sinan,Wilson, David M.
supporting information, p. 2245 - 2255 (2021/08/12)
Found in biomolecules, pharmaceuticals, ...
Decarboxylative Borylation of mCPBA-Activated Aliphatic Acids
Wei, Dian,Liu, Tu-Ming,Zhou, Bo,Han, Bing
supporting information, p. 234 - 238 (2020/01/02)
A decarboxylative borylation of aliphati...
Intramolecular Cyclization of Brominated Oxime Ether Promoted with Ytterbium(0) to the Synthesis of Cyclic Imines
Wang, Yiqiong,Huang, Fei,Zhang, Songlin
supporting information, p. 5178 - 5181 (2020/08/13)
The first utility of ytterbium(0) as a m...
1575-61-7 Process route
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773837-37-9
sodium cyanide
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110-56-5
1,4-dichlorobutane
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-
1575-61-7
5-Chlorovaleroyl chloride
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-
111-50-2
Adipic acid dichloride
| Conditions | Yield |
|---|---|
|
sodium cyanide; 1,4-dichlorobutane;
With
tetrabutylammomium bromide;
In
water;
at 80 - 85 ℃;
for 6h;
Large scale;
With
hydrogenchloride;
In
water;
at 55 - 70 ℃;
for 5h;
Large scale;
With
thionyl chloride;
at 20 - 30 ℃;
for 18h;
Large scale;
|
422 kg
163 kg |
-
-
1119-46-6
5-chloro-valeric acid
-
-
1575-61-7
5-Chlorovaleroyl chloride
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
for 3h;
Heating / reflux;
|
97%
|
|
With
thionyl chloride;
for 3h;
Heating / reflux;
|
97%
|
|
With
thionyl chloride;
for 3h;
Heating / reflux;
|
97%
|
|
With
thionyl chloride;
In
N,N-dimethyl-formamide;
at 75 ℃;
for 3h;
|
87%
|
|
With
oxalyl dichloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 23 ℃;
for 14h;
Inert atmosphere;
|
84%
|
|
With
thionyl chloride;
|
|
|
With
oxalyl dichloride;
Ambient temperature;
|
|
|
With
thionyl chloride;
In
dimethyl sulfoxide;
Heating;
|
8.52 g
|
|
With
oxalyl dichloride;
In
dichloromethane;
Inert atmosphere;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 25 ℃;
for 3h;
|
|
|
With
thionyl chloride;
for 2h;
Reflux;
Inert atmosphere;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 3h;
|
|
|
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 0 - 20 ℃;
|
1575-61-7 Upstream products
-
1119-46-6
5-chloro-valeric acid
-
638-29-9
n-valeryl chloride
-
7782-50-5
chlorine
-
71-43-2
benzene
1575-61-7 Downstream products
-
942-93-8
5-Chloro-1-phenyl-1-pentanone
-
17135-46-5
1-(4-fluorophenyl)-5-chloro-1-oxopentane
-
17135-50-1
1,5-bis(4-fluorophenyl)pentan-1-one
-
15865-18-6
N-(5-chloro-n-pentanoyl)cyclohexylamine