AMIKACIN

Base Information

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What is the AMIKACIN ?

AMIKACIN is , while it's Molecular Formula is C22H43N5O13. Amikacin is a semi-synthetic derivative of kanamycin. It is much less sensitive to the enzymes that inactivate aminoglycoside antibiotics. The spectrum is similar to that of gentamicin. Amikacin principally finds use in the treatment of infections arising from bacteria that are resistant to gentamicin and/or tobramycin.

What is the CAS number for AMIKACIN ?

The CAS number of AMIKACIN is 37517-28-5.

More information of AMIKACIN 37517-28-5 are:

Synonyms

1-N-[L-(-)-g-Amino-a-hydroxybutyryl]kanamycin A;Amukin;Antibiotic BB-K 8;Arikace;BB-K 8;Lukadin;Potentox;

CAS?Number

37517-28-5

Molecular Formula

C22H43N5O13

Molecular Weight

585.609

Density

1.6 g/cm3

Melting Point

203-204oC (sesquihydrate)

Boiling Point

981.8 °C at 760 mmHg

Flash Point

547.6 °C

HS CODE

29419090

PSA

331.94000

LogP

-5.23210

Pka

pKa 8.1 (Uncertain)

What is AMIKACIN (37517-28-5) used for?

Amikacin is made semisynthetically from kanamycin A. Interestingly, the L-hydroxyaminobutyryl amide (HABA) moiety attached to N-3 inhibits adenylation and phosphorylation in the distant amino sugar ring (at C-2′and C-3′), even though the HABA substituent is not where the enzymatic reaction takes place. This effect is attributed to decreased binding to the R factor–mediated enzymes.

InChI:InChI=1/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7?,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1

Articles related to AMIKACIN:

Article

Source

Preparation method for amikacin

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Paragraph 0024-0037; 0040-0042, (2020/06/24)

Preparation method of amikacin

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Paragraph 0029; 0032-0034; 0037; 0038, (2019/12/29)

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