Dimemorfan phosphate
Base Information
- Chemical Name: Dimemorfan phosphate
- CAS No.: 36304-84-4
99% Purity Commercial production Dimemorfan phosphate 36304-84-4 with Cheapest Price
- Molecular Formula: C18H25N*H3O4P
- Molecular Weight: 353.398
- Vapor Pressure: 1.42E-05mmHg at 25°C
- Melting Point: 267-269°
- Boiling Point: 366.9°Cat760mmHg
- Flash Point: 158.3°C
- PSA： 90.81000
- Density: 1.07g/cm3
- LogP: 2.69250
Dimemorfan phosphate(Cas 36304-84-4) Usage
|
Therapeutic Function |
Antitussive |
|
Safety Profile |
Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Used as an antitussive agent. When heated to decomposition it emits very toxic fumes of NOx and POx. |
InChI:InChI=1/C18H25N.H3O4P/c1-13-6-7-14-12-17-15-5-3-4-8-18(15,16(14)11-13)9-10-19(17)2;1-5(2,3)4/h6-7,11,15,17H,3-5,8-10,12H2,1-2H3;(H3,1,2,3,4)/t15-,17+,18+;/m1./s1
36304-84-4 Relevant articles
Preparation method of dimemorfan phosphate, and preparation methods of dimemorfan phosphate intermediates
-
, (2020/01/12)
The invention relates to a preparation m...
Preparation method of dimemorfan phosphate
-
Page/Page column 0035; 0036, (2018/09/21)
The invention relates to the field of ph...
An efficient synthesis of dimemorfan from dextromethorphan
Liu, Hui,Zheng, Wen-Yue,Ou, Xian-Fei,Ju, Xiu-Lian
, p. 214 - 219 (2015/05/27)
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36304-84-4 Process route
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-
36304-81-1,36304-82-2
Dimemorfan
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-
36304-84-4,40678-33-9
Dimemorfan phosphate
| Conditions | Yield |
|---|---|
|
With
phosphoric acid;
In
tert-butyl methyl ether; isopropyl alcohol;
|
88%
|
|
With
phosphoric acid;
In
ethanol;
at 20 ℃;
|
77.4%
|
-
-
1079043-47-2
(4bS,8aS,9S)-ethyl 3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate
-
-
36304-84-4,40678-33-9
Dimemorfan phosphate
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
4
steps
1.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C
2.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; lithium chloride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere
2.2: 120 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
4.1: phosphoric acid / tert-butyl methyl ether; isopropyl alcohol
With
bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; phosphoric acid; triethylamine; triphenylphosphine; lithium chloride;
In
tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; isopropyl alcohol;
|
36304-84-4 Upstream products
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1079043-47-2
(4bS,8aS,9S)-ethyl 3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate
-
524713-55-1
(4bS,8aS,9S)-ethyl 3-methoxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate
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1216910-34-7
(4bS,8aS,9S)-ethyl 3-(((trifluoromethyl)sulfonyl)oxy)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)-phenanthrene-11-carboxylate
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36304-81-1
Dimemorfan