Fevipiprant
Base Information
- Chemical Name: Fevipiprant
- CAS No.: 872365-14-5
Quality products?make an important contribution to long-term revenue and profitability. Chinese factory supply Fevipiprant 872365-14-5 in stock with high standard
1.What is the Fevipiprant ?
Fevipiprant is used in the oral treatment of asthma and has been successful in targeting severe eosinophilic asthma.Fevipiprant is a novel oral prostaglandin D2 receptor 2 (DP2; known as CRTh2) antagonist and currently in development for the treatment of severe asthma and atopic dermatitis.
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![2-methyl-1H-pyrrolo[2,3-b]pyridine](/upload/2026/6/fd31c2f51d4046a39bc0097b1831f44b_517fecec-d2e4-4000-89d3-eb603d8e751d.png)
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23612-48-8
2-methyl-1H-pyrrolo[2,3-b]pyridine
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![2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid](/upload/2026/6/2405116753a640bab0aa3a49da15ab6a_d9758455-1327-4204-97a7-f0242d0c8597.png)
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872365-14-5
2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
5
steps
1: butan-1-ol / Reflux
2: hydrogenchloride / water / Reflux
3: hydrogenchloride / water
4: sulfuric acid
5: caesium carbonate; magnesium sulfate / acetone / Reflux
With
hydrogenchloride; sulfuric acid; magnesium sulfate; caesium carbonate;
In
water; acetone; butan-1-ol;
1: |Mannich Aminomethylation;
|
|
|
Multi-step reaction
with
6
steps
1: butan-1-ol / Reflux
2: hydrogenchloride / water / Reflux
3: hydrogenchloride / water
4: sulfuric acid
5: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine / N,N-dimethyl-formamide
6: sodium hydroxide / water; tetrahydrofuran / 60 °C
With
hydrogenchloride; sulfuric acid; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; sodium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; butan-1-ol;
1: |Mannich Aminomethylation;
|
|
|
Multi-step reaction
with
4
steps
1.1: butan-1-ol / Reflux
2.1: water / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C
3.2: 100 °C
4.1: hydrogenchloride; water / 50 °C
With
hydrogenchloride; water; potassium carbonate;
In
water; N,N-dimethyl-formamide; butan-1-ol;
|
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![methyl 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate](/upload/2026/6/c28fd4e7364c4a57a317ba612125e962_2715f883-db79-44f3-9187-2351adb4b186.png)
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methyl 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate
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872365-14-5
2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid
| Conditions | Yield |
|---|---|
|
methyl 2-(1-{[4-methanesulfonyl-2-(trifluoromethyl)phenyl]methyl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate;
With
sodium hydroxide;
In
water;
at 50 ℃;
for 1h;
With
sulfuric acid;
In
n-heptane; water;
at 70 - 80 ℃;
pH=4 - 4.5;
|
75%
|
|
methyl 2-(1-{[4-methanesulfonyl-2-(trifluoromethyl)phenyl]methyl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate;
With
methanol; sodium hydroxide; water;
In
tetrahydrofuran;
at 20 ℃;
With
hydrogenchloride;
In
water;
pH=3 - 4;
|
|
|
methyl 2-(1-{[4-methanesulfonyl-2-(trifluoromethyl)phenyl]methyl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetate;
With
sodium hydroxide; water;
In
tetrahydrofuran;
at 20 ℃;
With
hydrogenchloride;
In
water;
pH=3 - 4;
Heating;
|
|
|
With
sodium hydroxide;
In
water; acetone;
at 20 ℃;
|
16.3 g
|
|
With
sodium hydroxide;
In
tetrahydrofuran; water;
at 60 ℃;
|
|
|
With
water; sodium hydroxide;
In
methanol; toluene;
at 25 - 30 ℃;
for 2h;
Reagent/catalyst;
Temperature;
Solvent;
Green chemistry;
|
37.5 g
|
2.What is the CAS number for Fevipiprant ?
The CAS number of Fevipiprant is 872365-14-5.
More information of Fevipiprant 872365-14-5 are:
|
CAS?Number |
872365-14-5 |
|
Density |
1.44±0.1 g/cm3(Predicted) |
|
Boiling Point |
637.6±55.0 °C(Predicted) |
|
HS CODE |
2933998090 |
|
Pka |
3.33±0.30(Predicted) |
3.What are another words for Fevipiprant ?
Synonyms?for?Fevipiprant 872365-14-5:
4.What is the molecular formula of Fevipiprant?
The chemical formula of ?Fevipiprant is?C19 H17 F3 N2 O4 S which containing 19 Carbon atoms,17 Hydrogen atoms,3 Fluorine atoms,2 Nitrogen atoms,4 Oxygen atoms and 1 Sulfur atoms,and the molecular weight of??Fevipiprant?is 426.416.
5.What is Fevipiprant (872365-14-5) used for?
Fevipiprant is a novel oral prostaglandin D2 receptor 2 (DP2; known as CRTh2) antagonist, which is currently in development for the treatment of severe asthma and atopic dermatitis. It has been successful in targeting severe eosinophilic asthma and is used in the oral treatment of this condition.
Relevant articles related to Fevipiprant:
|
Article |
Source |
|
Simple preparation method of prostaglandin D2 receptor inhibitor compound |
- Paragraph 0054-0058; 0061-0066, (2019/11/29) |
|
Fevipiprant selective prostaglandin DP2 (CRTh2) inhibitor treatment of asthma |
Singh,Saroj,Kumar,Kuhad,Kuhad , p. 565 - 572 (2018/09/11) |
6.Buy Fevipiprant with the best price .
tianjin xintaimei chemical co, ltd. is a quality supplier of Fevipiprant. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Fevipiprant 872365-14-5.