Methyl 2,2-dithienylglycolate
Base Information
- Chemical Name: Methyl 2,2-dithienylglycolate
- CAS No.: 26447-85-8
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1.What is the Methyl 2,2-dithienylglycolate ?
Intermediate in the production of Tiotropium Bromide, a long-acting bronchodilator.
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26447-85-8
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
| Conditions | Yield |
|---|---|
|
2-Bromthiophen, Dimethyloxalat;
|
|
|
(yield)47percent;
|
|
|
entspr. Thenil 1. KOH/H2O 2. konz. HCl 3. CH2N2;
|
|
|
analog Kadin, Cannon, J. Org. Chem. 27
<1962>
240;
|
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553-90-2
Dimethyl oxalate
-
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26447-85-8
hydroxy-di-thiophen-2-yl-acetic acid methyl ester
| Conditions | Yield |
|---|---|
|
2-bromothiophene;
With
magnesium;
In
diethyl ether;
at 0 - 35 ℃;
for 3h;
Dimethyl oxalate;
In
diethyl ether;
at 45 ℃;
for 0.75h;
Heating / reflux;
With
sulfuric acid;
at 20 ℃;
for 1h;
|
60%
|
2.What is the CAS number for Methyl 2,2-dithienylglycolate ?
The CAS number of Methyl 2,2-dithienylglycolate is 26447-85-8.
More information of Methyl 2,2-dithienylglycolate 26447-85-8 are:
|
CAS?Number |
26447-85-8 |
|
Density |
1.392 g/cm3 |
|
Boiling Point |
406.5 °C at 760 mmHg |
|
Flash Point |
199.6 °C |
|
Vapor Pressure |
2.46E-07mmHg at 25°C |
|
Refractive Index |
1.623 |
|
HS CODE |
2934999090 |
|
PSA |
103.01000 |
|
LogP |
2.21850 |
|
Pka |
10.43±0.29(Predicted) |
3.What are another words for Methyl 2,2-dithienylglycolate ?
Synonyms?for?Methyl 2,2-dithienylglycolate 26447-85-8:Glycolicacid, di-2-thienyl-, methyl ester (8CI);Di-2-thienylglycolic acid methylester;Hydroxydithien-2-ylacetic acidmethyl ester;Methyl di-2-thienylglycolate;Methyl di(2-thienyl)glycolate;
4.What is the molecular formula of Methyl 2,2-dithienylglycolate?
The chemical formula of ?Methyl 2,2-dithienylglycolate is?C11H10O3S2 which containing 11 Carbon atoms,10 Hydrogen atoms,3 Oxygen atoms and 2 Sulfur atoms,and the molecular weight of??Methyl 2,2-dithienylglycolate?is 254.331.
5.What is Methyl 2,2-dithienylglycolate (26447-85-8) used for?
Methyl 2,2-dithienylglycolate, also known as Methyl Di(2-thienylglycolate), is an organic compound that serves as an intermediate in the production of Tiotropium Bromide, a long-acting bronchodilator. It is characterized by its white solid appearance.
InChI:InChI=1/C11H10O3S2/c1-14-10(12)11(13,8-4-2-6-15-8)9-5-3-7-16-9/h2-7,13H,1H3
Relevant articles related to Methyl 2,2-dithienylglycolate:
|
Article |
Source |
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PROCESS FOR THE PURIFICATION OF METHYL-2,2-DITHIENYLGLYCOLATE |
- Page/Page column 13-14, (2019/07/17) |
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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: Identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2. 2.2]octane bromide (aclidinium bromide) |
Prat, María,Fernández, Dolors,Buil, M. Antonia,Crespo, María I.,Casals, Gaspar,Ferrer, Manuel,Tort, Laia,Castro, Jordi,Monleón, Juan M.,Gavaldà, Amadeu,Miralpeix, Montserrat,Ramos, Israel,Doménech, Teresa,Vilella, Dolors,Antón, Francisca,Huerta, Josep M.,Espinosa, Sonia,López, Manuel,Sentellas, Sonia,González, Marisa,Albertí, Joan,Segarra, Victor,Cárdenas, Alvaro,Beleta, Jorge,Ryder, Hamish supporting information; experimental part, p. 5076 - 5092 (2010/03/01) |
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